My dog's lymph node still swollen after antibiotics. Is it lymphoma?
Hello, sorry to hear about Giuseppe. Because the lymph node has decreased in size with antibiotics alone and the fact that only a single lymph node is enlarged, this is less likely consistent with lymphoma.
Lymphoma typically affects multiple nodes and does not respond to antibiotics. Occasionally, active lymph nodes may remain slightly enlarged for a few days, or if the infection is not being completely treated then the lymph node may remain big. The best way to confirm if this lymph node has lymphoma or not, would be to obtain cytology with a with a needle aspirate to have a pathologist examine the cells.
Cytology is generally a non-invasive procedure and could be done by your veterinarian.
Hope this helps and best of luck.
Updated on September 23, 2025